Half-time: Fulham 1 Liverpool 1

first_imgDaniel Sturridge equalised after Kolo Toure’s ninth-minute own goal had gifted Fulham the lead at Craven Cottage.Rene Meulensteen’s side, bottom of the Premier League but buoyed by Sunday’s draw at Manchester United, had Liverpool on the back foot straightaway and Simon Mignolet saved Ryan Tunnicliffe’s low shot in the opening minute.The Whites kept up the early pressure and Toure had to react quickly to prevent Darren Bent getting to Kieran Richardson’s left-wing cross.But the next time Richardson crossed from the left Toure contrived to slice the ball into his own net from close range.On-loan Tottenham midfielder Lewis Holtby almost doubled the lead with a 20-yard effort that fizzed just wide.And Bent headed over from seven yards out after being found by another Richardson cross.Having struggled for most of the first half, Liverpool levelled out of nothing four minutes before the interval.Steven Gerrard carved open the Fulham defence with a perfect through-ball and Sturridge fired in off the far post.Fulham: Stekelenburg; Riether, Heitinga, Burn, Riise; Tunnicliffe, Sidwell, Kvist, Richardson; Holtby; Bent. Subs: Stockdale, Hangeland, Kasami, Kačaniklić, Duff, Cole, Parker.Follow West London Sport on TwitterFind us on Facebooklast_img read more

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Nothing in Evolution Makes Sense Except in the Light of Speculation

first_imgWelcome to an imaginary world of Red Queens, Green Beards and warring armies: the world of evolutionary theory.  Though its adherents work in prestigious universities and laboratories in the real world, they seem preoccupied with speculative visions of imaginative fitness landscapes – even when defending evolutionary theory as the best explanation for natural phenomena, and essential for our understanding and progress in science.  This can be seen in two recent papers, one pro-evolution and one critical of it, that center on the question: is evolutionary theory essential to biology?    Ajit Varki defended evolution all the way down in a paper in Cell1 with the self-explanatory title, “Nothing in Glycobiology Makes Sense, except in the Light of Evolution.”  Adapting the title from a famous quote by Theodosius Dobzhansky, used more often as a club than a flashlight at school board hearings, Varki attempted to show the utility of evolutionary theory to one specialty: glycobiology, the study of biological sugars.  This is a complex field of unity and diversity, complexity and simplicity, conservation and diversification.  Cells use sugars inside and outside for a variety of functions, but pathogens also attach to them.  Glycobiology seems a confusing picture, from highly-conserved enzymes that have changed little from mouse to human, to variations within species and even within the lifetime of organisms.    In his defense of evolution to make sense of it all, he invokes the Red Queen effect (running in place to get nowhere: see 05/16/2004, 03/31/2006), co-evolution and evolutionary arms races.  It’s not clear, however, whether his presentation would convince a critic.  For one thing, most of his examples deal with microevolution, which is not controversial, even among the most ardent creationists.  The only exception is his treatment of possible means of speciation, one species splitting into two – which also fits within most creationist frameworks.  Nowhere in his article, however, does he explain how glycobiology needs evolution to explain the major changes most often implied by the term evolution.    A critic might also point out that Varki’s ideas are amply sweetened with speculation, by his own admission: “Whatever the reader might think of the speculations in this Essay,” he states in conclusion, “it is safe to suggest that approaches to understanding glycan biology must fully take into account the role of multiple and often simultaneous evolutionary processes, an aspect that has received limited attention.”  That seems an admission that many biologists have up till now not given it much attention – a contradiction to Dobzhansky’s claim.  It’s noteworthy how many times Varki’s scenarios are salted with qualifiers and peppered with hopes: The question that needs to be asked is not whether evolutionary theory may explain the phenomenon in question, but whether it is essential for any sensible explanation: whether or not “nothing makes sense except in the light of evolution.”  A Biblical creationist, for instance, might be perfectly content with certain aspects of these mechanisms at the microevolutionary level – evolutionary arms races and Red Queen effects – in a world cursed by sin and infected with pathogens.  He might claim that the Creator provided enough versatility for organisms to be able to adapt to changing environments, so that an animal would not be wiped out by the first encounter.  Yet the same creationist would still vehemently deny molecules-to-man evolution, the kind envisioned by Darwin and Dobzhansky.    Another assertion left unproved is whether biology really needs the kind of speculation Varki illustrated in its day-to-day business.  This question was taken up by a well-known critic of evolution, Jerry Bergman, who investigated whether practicing biologists actually illustrate Dobzhansky’s claim in their work.  In a recent article on TrueOrigin, Bergman concluded that Dobzhansky’s claim is a myth.  He interviewed scientists and researched textbooks, and found that evolutionary theory was rarely mentioned or used, and when it was, it was more an afterthought than a substantive part of the discussion:If, as Dobzhansky stated, “nothing in biology makes sense except in the light of evolution”…, why is it rarely, if ever, mentioned in most natural science books?  We usually use the leading college texts in each area (for example, the A&P text we use is the 10th edition of Hole, a standard text).  And why is it a minor topic even in most introductory biology books that cover the subject in more depth than most all other courses except formal classes on evolution?He concluded, “This statement is ideologically not factual.  Biology makes perfect sense without ever mentioning Darwinism.”  (See also the related entry from 08/30/2006).1Ajit Varki, “Nothing in Glycobiology Makes Sense, except in the Light of Evolution,” Cell, Volume 126, Issue 5, 8 September 2006, Pages 841-845, doi:10.1016/j.cell.2006.08.022.Varki inserted so many doubt-words into his text, it makes you wonder which side of the looking-glass he is on.  Despite his valiant effort, he only showed that evolution doesn’t buy you anything in theory.  Last week, Jerry Coyne showed (08/30/2006) that evolution doesn’t buy you anything in practice.  Conclusion: evolution is a bad investment.    While scientific freeloaders amuse themselves with “tantalizing speculations” in the Darwin Party lizard lounges (12/22/2003 commentary), the real work in science is being done by design (e.g., 07/21/2006, 06/29/2006, 06/22/2006).(Visited 58 times, 1 visits today)FacebookTwitterPinterestSave分享0 Overall, one can speculate that some episodes of speciation might be mediated by pathogens that bind to specific forms of cell-surface glycans.A lethal pathogen that binds to glycans of a certain species to initiate infection might markedly reduce the primary population, leaving geographically isolated subpopulations that have the opportunity to evolve into new species.Some of the survivors are likely to have been selected because of random glycan variations that allowed them to escape from infection with the pathogen.Such survivors may have secondary alterations in glycan biology that are permissive for pleiotropic changes in embryogenesis and/or morphogenesis.Glycan changes also might alter fertilization barriers, causing either reproductive isolation or anomalous fertilization by closely related species.Any or all of these mechanisms could support the formation of new species.  Many of these speculative ideas are testable by observational studies and possibly by long-term experiments.  [No examples cited.]Thus, glycans may be trapped in neverending cycles of evolutionary “Red Queen” effects in which long-lived hosts must evade the more rapidly evolving pathogens that infect them by changing their glycan expression patterns, without compromising their own survival (Van Valen, 1974 and Hamilton et al., 1990).  The colorful term, “Red Queen” effect, recalls the comment to Alice by the Red Queen in Lewis Carroll’s Through the Looking Glass that “it takes all the running you can do, to keep in the same place.”  This may explain the remarkable structural variations of glycans in nature, which contribute to biological diversity and perhaps even to speciation.Thus, the glycans of complex multicellular organisms with long life cycles may be subject to evolutionary “Red Queen” effects….For example, cell-type-specific expression of certain glycans can mediate specific biological roles within an organism (Lowe and Marth, 2003), which thus may be under positive selection.Additional Red Queen effects may arise from the fact that many pathogens use a successful form of molecular mimicry,…Such diversification and redundancy may be driven by sexual selection and sexual conflict….last_img read more

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Serena Williams set for 1st-round match at Indian Wells

first_imgPussycat Dolls set for reunion tour after 10-year hiatus Typhoon ‘Tisoy’ threatens Games LATEST STORIES Read Next Two-time winner Maria Sharapova returns to the desert for the first time in three years. She plays Naomi Osaka of Japan on Wednesday. Google honors food scientist, banana ketchup inventor and war hero Maria Orosa John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Police teams find crossbows, bows in HK university PLAY LIST 01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City LOOK: Iya Villania meets ‘Jumanji: The Next Level’ cast in Mexico Paul stars as Rockets top Thunder for 16th straight wincenter_img View comments Serena Williams of the United States reacts as a call goes against her and to opponent Zhang Shuai of China during the Tie Break Tens tournament at Madison Square Garden, Monday, March 5, 2018 in New York. Zhang defeated Williams to advance to the final round in the tournament but was defeated by Elina Svitolina. The Tie Break Tens’ New York event is a one-day day exhibition tournament featuring eight female players competing for a $250,000 winner’s prize. (AP Photo/Kathy Willens)INDIAN WELLS, Calif. — Serena Williams makes her return to the pro tour after a 14-month absence with a first-round match at the BNP Paribas Open on Thursday.She will play Zarina Diyas of Kazakhstan in a night match at the Indian Wells Tennis Garden.ADVERTISEMENT MOST READ Brace for potentially devastating typhoon approaching PH – NDRRMC Typhoon Kammuri accelerates, gains strength en route to PH Families in US enclave in north Mexico hold sad Thanksgiving Don’t miss out on the latest news and information. Williams has played just one Fed Cup doubles match while away from the WTA Tour. The former world No. 1 is unseeded and as a result did not receive a first-round bye.The new mother, who gave birth in September, will try to become the first woman to win three singles titles in the desert. Her other titles came in 1999 and 2001 before she boycotted the event for several years.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutWilliams, a winner of 23 Grand Slam titles, is in the same quarter of the draw as older sister Venus. The siblings could potentially face each other in the third round.Also set to play Thursday night is another new mom, Victoria Azarenka, a two-time tourney winner who got into the main draw with a wild card.last_img read more

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Deputy House Speaker urges PNP Administration to get economy moving

first_img Olive branch extended by Opposition Leader, says it is time for Turks and Caicos leaders to unite Recommended for you Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:economy, house of assembly, josephine connolly, pnp Opposition Leader responds to Throne Speech  11 days later; says PDM Govt plan puts TCI in ‘deep doo doo’ Facebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 19 Oct 2015 – The PNP Administration was called on to move faster and get the economy back on its feet by Deputy House Speaker and At Large Member from the PDM, Hon Josephine Connolly. During a very brief opening contribution in the House of Assembly last week, Connolly said it was concerning to her that so many residents still appear to be in financial crisis. “And when I checked the notice board Mr. Speaker, there is a list of 54 people who are about to lose their houses, 54. Mr. Speaker I have it in my hand, I can lay it on the table. But Mr. Speaker I say this to say that I think it is something that our government needs to look into and it is my hope that they speed up the process in getting this economy going so that our people can get jobs and pay their bills and so that they can have a comfortable life.” Reports to Magnetic Media mirror some social media remarks that, financially, it is still tough for many in the Turks and Caicos and that many people are uprooting and moving out of the country with a popular new home destination being, the UK. TCI Country Leaders condemn vicious memeslast_img read more

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Suspect steals credit cards from downtown gym spends 8000

first_img Posted: August 1, 2018 KUSI Newsroom, John Soderman, Categories: Local San Diego News FacebookTwitter Suspect steals credit cards from downtown gym, spends $8,000 Updated: 4:56 PMcenter_img KUSI Newsroom, John Soderman August 1, 2018 SAN DIEGO (KUSI) — Police are asking for the public’s help in identifying and locating a suspect who stole credit cards from a gym locker in downtown San Diego.The theft happened around 6:30 p.m. on July 9 at the AquaVie Fitness + Wellness Club located at 234 Broadway, San Diego Police Sgt. Matthew Botkin said.The suspect broke into a gym locker and stole four credit cards out of the victim’s wallet before racking up $8,000 in fraudulent purchases on the cards, Botkin said.Anyone with information about the identity or location of the suspect is asked to contact SDPD Detective Kevin Jankowski at (619) 744-9517. last_img read more

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House Blocked From Approving Disaster Aid Bill for Third Time

first_imgThe bipartisan $19.1 billion disaster aid bill stalled again Thursday when for the third time a GOP lawmaker objected to a request to approve the package by unanimous consent, CQ reported.Rep. John Rose (R-Tenn.) blocked the latest request, following previous procedural objections by Reps. Chip Roy (R-Texas) and Thomas Massie (R-Ky.).“This is absolutely, without a doubt wrong,” Rose said in blocking the latest request. He objected to the approval of nearly $20 billion in spending while the majority of lawmakers were out of Washington.The package, which gained approval from both the Senate and President Donald Trump late last week, is now expected to pass the House when lawmakers return Monday.The long-delayed disaster relief package includes $3.2 billion to rebuild military bases and Coast Guard facilities that have sustained extensive damage from natural disasters in the past year.Army photo by Staff Sgt. Austin Thomas ADC AUTHORlast_img read more

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